An Economical, Portable Manual Cryogenic Plunge Freezer for the Preparation of Vitrified Biological Samples for Cryogenic Electron Microscopy.

Visualizing biological structures and cellular processes in their native state is a major goal of many scientific laboratories. In the past 20 years, the technique of preserving samples by vitrification has greatly expanded, specifically for use in cryogenic electron microscopy (cryo-EM). Here, we report on improvements in the design and use of a portable manual cryogenic plunge freezer that is intended for use in laboratories that are not equipped for the cryopreservation of samples.

The construction of the instrument is economical, can be produced by a local machine shop without specialized equipment, and lowers the entry barriers for newcomers with a reliable alternative to costly commercial equipment. The improved design allows for successful freezing of isolated proteins for single particle analysis https://biodas.org/ as well as bacterial cells for cryo-electron tomography. With this instrument, groups will be able to prepare vitreous samples whenever and wherever necessary, which can then be imaged at local or national cryo-EM facilities.

Successful short-term cryopreservation of volume-reduced cord blood units in a cryogenic mechanical freezer: effects on cell recovery, viability, and clonogenic potential

BACKGROUND
Cord blood (CB) units are stored from weeks to years in liquid- or vapor-phase nitrogen until they are used for transplantation. We examined the effects of cryostorage in a mechanical freezer at -150°C on critical quality control variables of CB collections to investigate the possible use of mechanical freezers at -150°C as an alternative to storage in liquid- (or vapor-) phase nitrogen.
METHODS
A total of 105 CB units were thawed and washed at different time intervals (6, 12, 24, and 36 months). For every thawed CB unit, samples were removed and cell enumeration (total nucleated cells [TNCs], mononuclear cells [MNCs], CD34+, CD133+) was performed. In addition, viability was obtained with the use of flow cytometry, and recoveries were calculated. Also, total absolute colony-forming unit counts were performed and progenitor cell recoveries were studied by clonogenic assays.
RESULTS
Significant differences (p < 0.05) were observed in certain variables (TNCs, MNC numbers, viability) when they were examined in relation with time intervals, while others (CD34+, CD133+) were relatively insensitive (p = NS) to the duration of time interval the CB units were kept in cryostorage condition.
CONCLUSIONS
The data presented suggest that cryopreservation of CB units in a mechanical freezer at -150°C may represent an alternative cryostorage condition for CB cryopreservation.

Realignment-free cryogenic macroscopic optical cavity coupled to an optical fiber

We present a cryogenic setup where an optical Fabry-Perot resonator is coupled to a single-mode optical fiber with coupling efficiency above 90% at mK temperatures without realignment during cooling down. The setup is prealigned at room temperature to compensate for the thermal contraction and change of the refractive index of the optical components during cooling down.

The high coupling efficiency is achieved by keeping the setup rotation-symmetric around the optical axis. The majority of the setup components are made of Invar (FeNi36), which minimizes the thermal contraction. High coupling efficiency is essential in quantum optomechanical experiments.

Extraordinary approach to further boost plasmonic NIR-SERS by cryogenic temperature-suppressed non-radiative recombination

We report an effective strategy to promote the near-infrared surface-enhanced Raman scattering spectroscopy (NIR-SERS) activity by boosting the photon-induced charge transfer (PICT) efficiency at cryogenic temperature. Based on as-prepared Au/Ag nano-urchins (NUs) with abundant surface defects, the extremely low temperature (77 K) can significantly weaken the metallic lattice vibration and reduce the recombination of thermal phonons and photoexcited electrons, then accelerate the migration of energetic electrons.
It enables the NIR-SERS detection limit of dye molecules to be achieved at 10-17 M, which is nearly three orders of magnitude better than that at room temperature. The present work provides a new, to the best of our knowledge, approach for ultra-trace NIR-SERS bioanalysis.

Ultra-stretchable and fast self-healing ionic hydrogel in cryogenic environments for artificial nerve fiber

Self-healing materials behave irreplaceable advantages in biomimetic intelligent robots (BIR) for avoiding or reducing safety hazards and economic losses from accidental damage during service. However, the self-healing ability is unreservedly lost and even becomes rigid, fragile in the cryogenic environment where BIR is precisely needed. Here, we report a versatile ionic hydrogel with fast self-healing ability, ultra-stretchability, and stable conductivity, even at -80℃.
The hydrogel is systematically optimized to improve hydrogen-bonded network nanostructure, coordinated achieving a quick self-healing ability within 10 min, large deformation tolerance of over 7000%, superior conductivity of 11.76 S·cm-1 and anti-freezing ability, which is difficult to obtain simultaneously. Such hydrogel provides new opportunities for artificial electronic devices in harsh environments. As a prospective application, we fabricate an artificial nerve fiber by mimicking the structure and functions of the myelinated axon, exhibiting the property of fast and potential-gated signal transmission.
This artificial nerve fiber is integrated into a robot for demonstrating a real-time high fidelity and high throughput information interaction under big deformation and cryogenic temperature. The hydrogel and bionic device will bring pioneering functions for robots and open a broad application scenario in extreme conditions. This article is protected by copyright. All rights reserved.

Cryogenic temperature sensing based on the temperature dependence of color centers in optical fibers

A cryogenic temperature sensor based on the temperature dependence of stable color centers in a commercial single-mode optical fiber is proposed. The radiation induced attenuation spectra at different temperatures are measured and decomposed by Ge-NBOHC and Ge(X) color centers. The configurational coordinate model is used to explain the temperature properties of the color centers.
A series of experiments are conducted to evaluate its performance in the temperature range from 10°C to -196°C, and the results suggest that the temperature sensitivity is ∼0.17 dB/km/°C with a resolution of 0.034°C, and the nonlinearity and repeatability error are ±3.8% and 1.4%, respectively.

Revealing the Intrinsic Atomic Structure and Chemistry of Amorphous LiO 2-Containing Products in Li-O 2 Batteries Using Cryogenic Electron Microscopy

Aprotic lithium-oxygen batteries (LOBs) are promising energy storage systems characterized by ultrahigh theoretical energy density. Extensive research has been devoted to this battery technology, yet the detailed operational mechanisms involved, particularly unambiguous identification of various discharge products and their specific distributions, are still unknown or are subjects of controversy. This is partly because of the intrinsic complexity of the battery chemistry but also because of the lack of atomic-level insight into the oxygen electrodes acquired via reliable techniques. In the current study, it is demonstrated that electron beam irradiation could induce crystallization of amorphous discharge products. Cryogenic conditions and a low beam dosage have to be used for reliable transmission electron microscopy (TEM) characterization.
High-resolution cryo-TEM and electron energy loss spectroscopy (EELS) analysis of toroidal discharge particles unambiguously identified the discharge products as a dominating amorphous LiO2 phase with only a small amount of nanocrystalline Li2O2 islands dispersed in it. In addition, uniform mixing of carbon-containing byproducts is identified in the discharge particles with cryo-EELS, which leads to a slightly higher charging potential. The discharge products can be reversibly cycled, with no visible residue after full recharge. We believe that the amorphous superoxide dominating discharge particles can lead researchers to reconsider the chemistry of LOBs and pay special attention to exclude beam-induced artifacts in traditional TEM characterizations.

Tissue and Cell Extraction and Purification

EP10011 Neuromics 100 Tests 636 EUR

p5 Ligand for Dnak and and DnaJ

5-01680 CHI Scientific 4 x 5mg Ask for price

Linsmaier and Skoog, With macro- and micronutrients

CP021-010 GenDepot 10X1L 101 EUR

Linsmaier and Skoog, With macro- and micronutrients

CP021-500 GenDepot 50L 126 EUR

Murashige and Skoog, With Vitamins and Glycine

CP031-010 GenDepot 10X1L 99 EUR

Murashige and Skoog, With Vitamins and Glycine

CP031-500 GenDepot 50L 126 EUR

p5 Ligand for Dnak and and DnaJ Peptide

20-abx266082 Abbexa
  • 411.00 EUR
  • 662.00 EUR
  • 314.00 EUR
  • 10 mg
  • 25 mg
  • 5 mg

Murashige and Skoog

CP023-010 GenDepot 10X1L 99 EUR

Murashige and Skoog

CP023-500 GenDepot 50L 126 EUR

Nitsch and Nitsch

CP036-010 GenDepot 10X1L 101 EUR

Nitsch and Nitsch

CP036-500 GenDepot 50L 126 EUR

Shenk and Hildebrandt

CP038-010 GenDepot 10X1L 101 EUR

Shenk and Hildebrandt

CP038-500 GenDepot 50L 126 EUR

Recombinant Human AND

P0015 FN Test 100ug 522.36 EUR

Mouse Ariway PrimaCell3: Normal Bronchial and and Tracheal Fibroblasts

2-82003 CHI Scientific 1 Kit Ask for price

Rat Ariway PrimaCell3: Normal Bronchial and and Tracheal Fibroblasts

2-82503 CHI Scientific 1 Kit Ask for price

Human Airway PrimaCell4: Normal Bronchial and and Tracheal Fibroblasts

2-96004 CHI Scientific 1 Kit Ask for price

Murashige and Skoog, 1/2 Micronutrients and 1/2 Iron

CP024-010 GenDepot 10X1L 99 EUR

Murashige and Skoog, 1/2 Micronutrients and 1/2 Iron

CP024-500 GenDepot 50L 126 EUR

Murashige and Skoog, With Vitamins, Glycine, and 30g/L Sucrose

CP032-010 GenDepot 10X1L 101 EUR

Murashige and Skoog, With Vitamins, Glycine, and 30g/L Sucrose

CP032-500 GenDepot 50L 126 EUR

RNase and DNAase Away

DB0339 Bio Basic 200ml 72.62 EUR

Blunting and Ligation Kit

BS243 Bio Basic 10Preps 102.2 EUR

cool-pack and platfom

EHS1300-COOL Consort ea 124 EUR

cool-pack and platfom

EHS1400-COOL Consort ea 124 EUR

cool-pack and platfom

EHS1500-COOL Consort ea 149 EUR

Mutations in the receptor-binding domain of human SARS CoV-2 spike protein increases its affinity to bind human ACE-2 receptor

The severe acute respiratory syndrome virus-2 (SARS CoV-2) infection has resulted in the current global pandemic. The binding of SARS CoV-2 spike protein receptor-binding domain (RBD) to the human angiotensin converting enzyme-2 (ACE-2) receptor causes the host infection. The spike protein has undergone several mutations with reference to the initial strain isolated during December 2019 from Wuhan, China. A number of these mutant strains have been reported as variants of concern and as variants being monitored. Some of these mutants are known to be responsible for increased transmissibility of the virus.
The reason for the increased transmissibility caused by the point mutations can be understood by studying the structural implications and inter-molecular interactions in the binding of viral spike protein RBD and human ACE-2. Here, we use the crystal structure of the RBD in complex with ACE-2 available in www.joplink.net/coronavirus-proteins/ the public domain and analyse the 250 ns molecular dynamics (MD) simulations of wild-type and mutants; K417N, K417T, N440K, N501Y, L452R, T478K, E484K and S494P.
The ionic, hydrophobic and hydrogen bond interactions, amino acid residue flexibility, binding energies and structural variations are characterized. The MD simulations provide clues to the molecular mechanisms of ACE-2 receptor binding in wild-type and mutant complexes. The mutant spike proteins RBD were associated with greater binding affinity with ACE-2 receptor. Communicated by Ramaswamy H. Sarma.

COVID-19 and Alzheimer’s disease: Meninges-mediated neuropathology

SARS-CoV-2 the causative agent of COVID-19 displays a broad range of pathophysiology. Cytokine storms associated with COVID-19 damage the blood-brain barrier (BBB) and allow pro-inflammatory factors to invade the brain, further promoting neurodegeneration. While SARS-CoV-2 viral RNA and proteins have been detected in brain tissues, the mechanisms of neuroinvasion remain unknown. COVID-19 has had a disproportionate impact on those suffering from neurodegenerative disorders such as Alzheimer’s disease (AD).
Understanding the mechanisms of SARS-CoV-2 neuroinvasion is crucial to study the long-term neurocognitive effects of COVID-19 on AD pathology.
Viruses can infiltrate the brain through the meninges via infected immune cells. The meninges regulate the immune surveillance of the brain and play a key role in the efflux of pathogens from the brain. Meningeal dysfunction has been demonstrated to exacerbate amyloid-beta pathogenesis. In this study, we explore the neuroinvasion pathway of SARS-CoV-2 through the meninges and its effect on AD pathology.
Method: 5x FAD x hACE2 mice were inoculated intranasally with a sublethal dose of SARS-CoV-2. The mice were maintained for 2 weeks. Mouse brains and meninges were harvested. The tissue was stained and immunofluorescence imaging was conducted to study viral proliferation and immune responses. Histo-cytometry was conducted for quantitative imaging analysis. Gene expression studies were done using Nanostring assays. All experiments involving the SARS-Cov-2 virus were carried out in a BSL3 facility.
Result: This ongoing study demonstrates the proliferation of the SARS-CoV-2 virus in the brain via meningeal lymphatics. SARS-CoV-2 infection resulted in increased neuroinflammation. Additionally, inflammatory responses induced meningeal dysfunction resulting in increased amyloid-beta pathology and cerebrospinal fluid drainage.
Conclusion: Given the increasing evidence for a viral hypothesis of Alzheimer’s Disease it is extremely important to study the neurodegenerative effects of COVID-19 which has affected millions worldwide. We demonstrate that SARS-CoV-2 infiltrates the brain via the meninges promoting neuroinflammation. Furthermore, amyloid-beta pathologies are exacerbated by COVID-19 in animal models providing preclinical evidence of the long-term neurodegenerative effects of COVID-19.

Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by beta-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has rapidly spread across the globe starting from February 2020. It is well established that during viral infection, extracellular vesicles become delivery/presenting vectors of viral material. However, studies regarding extracellular vesicle function in COVID-19 pathology are still scanty. Here, we performed a comparative study on exosomes recovered from the plasma of either MILD or SEVERE COVID-19 patients.
We show that although both types of vesicles efficiently display SARS-CoV-2 spike-derived peptides and carry immunomodulatory molecules, only those of MILD patients are capable of efficiently regulating antigen-specific CD4+ T-cell responses. Accordingly, by mass spectrometry, we show that the proteome of exosomes of MILD patients correlates with a proper functioning of the immune system, while that of SEVERE patients is associated with increased and chronic inflammation.
Overall, we show that exosomes recovered from the plasma of COVID-19 patients possess SARS-CoV-2-derived protein material, have an active role in enhancing the immune response, and possess a cargo that reflects the pathological state of patients in the acute phase of the disease.

Role of SARS-CoV-2 in causing blood-brain barrier leakage and microglial activation as a risk factor of cognitive deterioration in subjects at risk of Alzheimer’s disease

The recent pandemic provides evidence of altered central nervous system (CNS) function in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-COV-2 invades the CNS by binding angiotensin-converting enzyme 2 (ACE2) expressed on neurons and glia. SARS-COV-2 may have effects on increased permeability of endothelial cells within the blood-brain barrier (BBB) as studies have shown that the S1 protein can transverse the BBB.
This is interesting because leakage of the BBB is implicated in Alzheimer’s disease (AD) pathogenesis. We hypothesized that SARS-CoV-2 infection leads to innate stimulated inflammation, ultimately activating microglial cells and an influx of pro-inflammatory cytokines and leukocytes in the meninges, contributing to increased permeability of the BBB. This BBB permeability increases AD susceptibility in subjects at risk by causing irreversible damage to the BBB and microglial cell activation.
Method: We developed a double transgenic mouse model using mice expressing human ACE2 receptor and 5xFAD mice that exhibit increased neuropathology seen in human AD allowing modeling of AD in SARS-CoV-2 pathogenesis. The hACE2/5xFAD double transgenic mice were intranasally inoculated with a sub-lethal dose of SARS-CoV-2 to test the hypothesis that SARS-COV-2 potentiates AD pathology and cognitive deterioration through impairment of the BBB. Leukocyte and cytokine populations were measured by flow cytometry and single-nuclei RNA sequencing of the meninges for characterization of microglial populations.
Result: SARS-CoV-2 creates a cytotoxic environment in the brain immediately following infection in hACE2/5xFAD mice leading to leakage of the BBB in the meninges. Activation of microglial innate cells by SARS-COV-2 invasion of the CNS will cause neural deterioration having long term implications on cognitive function. The hACE2/5xFAD mouse model allows us to uncover implications for SARS-COV-2 on AD cognitive deterioration.
Conclusion: The hACE2/5xFAD mouse allows modeling of SARS-CoV-2 in developing AD cases and allowed us to determine the immune environment generated in the meninges in response to SARS-CoV-2 infections. This mouse model provides a platform to proactively determine the effects of SARS-CoV-2 in developing AD cases, a methodology to be exploited for future mouse models determining the relationship of other viruses on AD pathology, and the opportunity to address phenotypes with therapeutics for preventative initiatives.

Recombinant SARS SARS Core Protein, Untagged, E.coli-100ug

100ug 218 EUR

Recombinant SARS SARS Core Protein, Untagged, E.coli-1mg

1mg 1061 EUR

Recombinant SARS SARS Core Protein, Untagged, E.coli-500ug

500ug 663 EUR

Recombinant SARS SARS Core Protein, Untagged, E.coli-100ug

100ug 218 EUR

Recombinant SARS SARS Core Protein, Untagged, E.coli-1mg

1mg 1061 EUR

Recombinant SARS SARS Core Protein, Untagged, E.coli-500ug

500ug 663 EUR

Recombinant SARS SARS Envelope Protein, Untagged, E.coli-100ug

100ug 218 EUR

Recombinant SARS SARS Envelope Protein, Untagged, E.coli-1mg

1mg 1061 EUR

Recombinant SARS SARS Envelope Protein, Untagged, E.coli-500ug

500ug 663 EUR

Recombinant SARS SARS Matrix Protein, Untagged, E.coli-100ug

100ug 218 EUR

Perspectives of farmers and tourists on agricultural abandonment in east Lesvos, Greece.

Perspectives of farmers and tourists on agricultural abandonment in east Lesvos, Greece.

Multi-stakeholder perceptions of panorama modifications are more and more acknowledged as important inputs to discussions on future panorama developments, significantly when addressing the way forward for European rural areas experiencing agricultural abandonment.

This analysis presents a case exploration of abandonment of olive plantations in east Lesvos, Greece. We carried out two units of semi-structured interviews to narrate an exploration on native farmers’ capacity and willingness to keep up the plantations, to the outcomes of a panorama choice survey undertaken with vacationers. Three farmer varieties are recognized following a cluster evaluation based mostly on attributes of particular person capacity and willingness to farm. Farmers belonging to the prevalent kind revealed low capacity and willingness and count on to additional extensify their farms.

The remaining two farmer varieties have greater willingness; they’re motivated by cultural causes, extra incessantly expressing a want to keep up their land underneath household possession, and partake in social cooperative initiatives selling practices valorizing the olive plantations. We define how these varieties work together with regional drivers of change, and partly additionally contribute to persistence of abandonment by way of constrained capacity to farm.

Abandonment doesn’t align with present panorama preferences of vacationers, who favor cultivated landscapes, components of traditionality inside constructed infrastructure and undertake nature-based actions. We focus on how excessive willingness to farm related to skilled and pluri-active types of farming could nevertheless present alternatives to keep up the cultivated panorama and synergize with (agri-)tourism demand. Our findings are corresponding to these of different European research, contributing to discussions on the way forward for its rural landscapes.

Perspectives of farmers and tourists on agricultural abandonment in east Lesvos, Greece.
Views of farmers and vacationers on agricultural abandonment in east Lesvos, Greece.

Immunophenotypic characterization, multi-lineage differentiation and growing older of zebrafish coronary heart and liver tissue-derived mesenchymal stem cells as a novel strategy in stem cell-based remedy.

Mesenchymal stem cells (MSCs) are a very good mannequin for preclinical and scientific investigations, and various sources of MSCs are topic to intensive experiments. On this examine, mesenchymal stem cells (MSCs) have been remoted from coronary heart and liver tissue of Zebrafish (Danio rerio). The flow-cytometry in addition to RT-PCR have been used to investigate the expression of a panel of cell floor markers CD44, CD90, CD31 and CD34.

Paritaprevir(ABT-450)

20-abx184297
  • EUR 1247.00
  • EUR 913.00
  • 10 mg
  • 5 mg

AKT1 (Ab-450) Antibody

CSB-PA969941-
EUR 335
Description: A polyclonal antibody against AKT1 (Ab-450). Recognizes AKT1 (Ab-450) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

AKT1 (Ab-450) Antibody

CSB-PA969941-100ul 100ul
EUR 316
Description: A polyclonal antibody against AKT1 (Ab-450). Recognizes AKT1 (Ab-450) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

iFluor™ 450 maleimide

1057 1 mg
EUR 219

AKT1 (Ab-450) Antibody

21502-100ul 100ul
EUR 252

AKT1 (Ab-450) Antibody

21502-50ul 50ul
EUR 187

Nhe I unit: 450

YRNHE1 1 vial Ask for price

anti-AKT1 (Ab-450)

LF-PA20679 100 ul
EUR 334
Description: Rabbit polyclonal to AKT1

mFluor™ Violet 450 acid

1140 5 mg
EUR 219

mFluor™ Violet 450 SE

1150 1 mg
EUR 219

mFluor™ 450-VAD-FMK

13475 25 Tests
EUR 132

Polyclonal SNX4 Antibody (aa438-450)

AMM07924G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human SNX4 (aa438-450). This antibody is tested and proven to work in the following applications:

Polyclonal CYP1B1 Antibody (aa400-450)

APG02857G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CYP1B1 (aa400-450). This antibody is tested and proven to work in the following applications:

Polyclonal TLR1 Antibody (aa400-450)

APR02824G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TLR1 (aa400-450). This antibody is tested and proven to work in the following applications:

Polyclonal PACSIN2 Antibody (aa400-450)

APR17733G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PACSIN2 (aa400-450). This antibody is tested and proven to work in the following applications:

AKT1 (Ab-450) Conjugated Antibody

C21502 100ul
EUR 397

GFP-Rac1 Expression Vector Set

STA-450 1 kit
EUR 1616
Description: GFP-Rac1 Expression Vector Set contains 3 vectors: Rac wild type, T17N dominant negative mutant, and Q61L constitutively active mutant. Each vector also contains a GFP reporter sequence.

Recombinant (CHO cells) Hepatitis B Surface Antigen adr subtype (HBsAg)

RP-450 20 ug
EUR 164

Filter for Accuris Microplate Reader

MR9600-450 1 PC
EUR 201.3

Her2 / ErbB2 Recombinant Protein

11-450 0.1 mg
EUR 542.75
Description: Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

CSF3 Recombinant Protein

90-450 10 ug
EUR 364.25
Description: G-CSF is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation and activation of hematopoietic cells of the neutrophilic granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNF-alpha and IFN-gamma. Other cell types including fibroblasts, endothelial cells, astrocytes and bone marrow stromal cells can also secrete G-CSF after LPS, IL-1 or TNF-alpha activation. In addition, various carcinoma cell lines and myeloblastic leukemia cells can express G-CSF constitutively. G-CSF stimulates growth, differentiation and functions of cells from the neutrophil lineage in vitro. Consistent with its in vitro functions, G-CSF has been found to play important roles in defense against infection, in inflammation and repair and in the maintenance of steady state hematopoiesis. Recombinant human G-CSF has been approved for the amelioration of chemotherapy induced neutropenia as well as for severe chronic neutropenia following marrow transplant.

VEGF-D Recombinant Protein

91-450 0.05 mg
EUR 542.75
Description: Vascular endothelial growth factor D (VEGF-D) is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. It is highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas. VEGF-D is growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. It may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. It undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors.

HLADG Recombinant Protein

92-450 0.05 mg
EUR 490.25
Description: Mouse HLA class II histocompatibility antigen gamma chain (CD74), is a single-pass type II membrane protein that in humans is encoded by the CD74 gene. It contains 1 thyroglobulin type-1 domain. CD74 Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

mFluor™ Violet 450-streptavidin conjugate

16930 100 ug
EUR 132

Polyclonal CYP24 / CYP24A1 Antibody (aa400-450)

APG02862G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CYP24 / CYP24A1 (aa400-450). This antibody is tested and proven to work in the following applications:

Annexin V-mFluor™ Violet 450 conjugate

20080 100 tests
EUR 219

Polyclonal OLFM4 / Olfactomedin 4 Antibody (aa400-450)

APR02466G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human OLFM4 / Olfactomedin 4 (aa400-450). This antibody is tested and proven to work in the following applications:

Polyclonal TUBB / Beta Tubulin Antibody (aa401-450)

APR13866G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TUBB / Beta Tubulin (aa401-450). This antibody is tested and proven to work in the following applications:

Recombinant Salmonella envZ Protein (aa 1-450)

VAng-Wyb0428-inquire inquire Ask for price
Description: Salmonella typhi Osmolarity sensor protein EnvZ, recombinant protein.

Recombinant Mycobacterium Tuberculosis aroA Protein (aa 1-450)

VAng-Yyj0406-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Mycobacterium Tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase (aroA), recombinant protein.

Recombinant Mycobacterium Tuberculosis mbtI Protein (aa 1-450)

VAng-Yyj0512-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Mycobacterium Tuberculosis Isochorismate synthase/isochorismate-pyruvate lyase mbtI (mbtI), recombinant protein.

Recombinant Mycobacterium Paratuberculosis mbtI Protein (aa 1-450)

VAng-Yyj0959-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Mycobacterium Paratuberculosis Isochorismate synthase/isochorismate-pyruvate lyase mbtI (mbtI), recombinant protein.

Polyclonal HTR2C / 5-HT2C Receptor Antibody (aa400-450)

APR07860G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HTR2C / 5-HT2C Receptor (aa400-450). This antibody is tested and proven to work in the following applications:

Monoclonal TUBB3 / Tubulin Beta 3 Antibody (aa436-450)

APR13878G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human TUBB3 / Tubulin Beta 3 (aa436-450). The antibodies are raised in Mouse. This antibody is applicable in WB and IHC-P, ICC

Recombinant Mycobacterium Vanbaalenii mshA Protein (aa 1-450)

VAng-Yyj5250-1mgEcoli 1 mg (E. coli)
EUR 5054
Description: Mycobacterium Vanbaalenii (strain DSM 7251 / PYR-1) D-inositol 3-phosphate glycosyltransferase (mshA), recombinant protein.

Recombinant Mycobacterium Vanbaalenii mshA Protein (aa 1-450)

VAng-Yyj5250-500gEcoli 500 µg (E. coli)
EUR 3569
Description: Mycobacterium Vanbaalenii (strain DSM 7251 / PYR-1) D-inositol 3-phosphate glycosyltransferase (mshA), recombinant protein.

Recombinant Mycobacterium Vanbaalenii mshA Protein (aa 1-450)

VAng-Yyj5250-50gEcoli 50 µg (E. coli)
EUR 2443
Description: Mycobacterium Vanbaalenii (strain DSM 7251 / PYR-1) D-inositol 3-phosphate glycosyltransferase (mshA), recombinant protein.

Recombinant Streptococcus Pneumoniae glmM Protein (aa 1-450)

VAng-Ly1119-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Streptococcus Pneumoniae Phosphoglucosamine mutase, recombinant protein.

Recombinant Schizosaccharomyces Pombe SPBC409.19c Protein (aa 1-450)

VAng-Yyj6525-1mgEcoli 1 mg (E. coli)
EUR 5384
Description: Schizosaccharomyces Pombe (strain 972 / ATCC 24843) (Fission yeast) Metaxin-like protein C409.19c (SPBC409.19c), recombinant protein.

Recombinant Schizosaccharomyces Pombe SPBC409.19c Protein (aa 1-450)

VAng-Yyj6525-500gEcoli 500 µg (E. coli)
EUR 3569
Description: Schizosaccharomyces Pombe (strain 972 / ATCC 24843) (Fission yeast) Metaxin-like protein C409.19c (SPBC409.19c), recombinant protein.

Recombinant Schizosaccharomyces Pombe SPBC409.19c Protein (aa 1-450)

VAng-Yyj6525-50gEcoli 50 µg (E. coli)
EUR 2443
Description: Schizosaccharomyces Pombe (strain 972 / ATCC 24843) (Fission yeast) Metaxin-like protein C409.19c (SPBC409.19c), recombinant protein.

Recombinant Escherichia coli creD Protein (aa 1-450)

VAng-Lsx02251-inquire inquire Ask for price
Description: Escherichia coli (strain K12) Inner membrane protein CreD, recombinant protein.

Recombinant Escherichia coli envZ Protein (aa 1-450)

VAng-Lsx02364-inquire inquire Ask for price
Description: Escherichia coli (strain K12) Osmolarity sensor protein EnvZ, recombinant protein.

Recombinant Escherichia coli rseP Protein (aa 1-450)

VAng-Lsx02612-inquire inquire Ask for price
Description: Escherichia coli (strain K12) Regulator of sigma E protease, recombinant protein.

Recombinant Shigella Dysenteriae wzyE Protein (aa 1-450)

VAng-Lsx07570-inquire inquire Ask for price
Description: Shigella Dysenteriae serotype 1 (strain Sd197) Putative ECA polymerase, recombinant protein.

Recombinant Shigella Flexneri envZ Protein (aa 1-450)

VAng-Lsx07730-inquire inquire Ask for price
Description: Shigella Flexneri Osmolarity sensor protein EnvZ, recombinant protein.

Recombinant Helicobacter Pylori mnmE Protein (aa 1-450)

VAng-Lsx3295-1mgEcoli 1 mg (E. coli)
EUR 5303
Description: Helicobacter Pylori tRNA modification GTPase MnmE, recombinant protein.

Recombinant Helicobacter Pylori mnmE Protein (aa 1-450)

VAng-Lsx3295-500gEcoli 500 µg (E. coli)
EUR 3583
Description: Helicobacter Pylori tRNA modification GTPase MnmE, recombinant protein.

Recombinant Helicobacter Pylori mnmE Protein (aa 1-450)

VAng-Lsx3295-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Helicobacter Pylori tRNA modification GTPase MnmE, recombinant protein.

Recombinant Helicobacter Pylori mqo Protein (aa 1-450)

VAng-Lsx3309-1mgEcoli 1 mg (E. coli)
EUR 5303
Description: Helicobacter Pylori Probable malate:quinone oxidoreductase, recombinant protein.

Recombinant Helicobacter Pylori mqo Protein (aa 1-450)

VAng-Lsx3309-500gEcoli 500 µg (E. coli)
EUR 3583
Description: Helicobacter Pylori Probable malate:quinone oxidoreductase, recombinant protein.

Recombinant Helicobacter Pylori mqo Protein (aa 1-450)

VAng-Lsx3309-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Helicobacter Pylori Probable malate:quinone oxidoreductase, recombinant protein.

Recombinant Bordetella Avium mnmE Protein (aa 1-450)

VAng-Lsx4162-1mgEcoli 1 mg (E. coli)
EUR 5303
Description: Bordetella Avium tRNA modification GTPase MnmE, recombinant protein.

Recombinant Bordetella Avium mnmE Protein (aa 1-450)

VAng-Lsx4162-500gEcoli 500 µg (E. coli)
EUR 3583
Description: Bordetella Avium tRNA modification GTPase MnmE, recombinant protein.

Recombinant Bordetella Avium mnmE Protein (aa 1-450)

VAng-Lsx4162-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Bordetella Avium tRNA modification GTPase MnmE, recombinant protein.

Recombinant Candida Albicans SAH1 Protein (aa 1-450)

VAng-Lsx05911-1mgEcoli 1 mg (E. coli)
EUR 5054
Description: Candida Albicans (strain SC5314 / ATCC MYA-2876) Adenosylhomocysteinase, recombinant protein.

Recombinant Candida Albicans SAH1 Protein (aa 1-450)

VAng-Lsx05911-500gEcoli 500 µg (E. coli)
EUR 3569
Description: Candida Albicans (strain SC5314 / ATCC MYA-2876) Adenosylhomocysteinase, recombinant protein.

Recombinant Candida Albicans SAH1 Protein (aa 1-450)

VAng-Lsx05911-50gEcoli 50 µg (E. coli)
EUR 2443
Description: Candida Albicans (strain SC5314 / ATCC MYA-2876) Adenosylhomocysteinase, recombinant protein.

Recombinant Mycoplasma Capricolum dnaA Protein (aa 1-450)

VAng-Lsx06178-1mgEcoli 1 mg (E. coli)
EUR 5054
Description: Mycoplasma Capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) Chromosomal replication initiator protein DnaA, recombinant protein.

Recombinant Mycoplasma Capricolum dnaA Protein (aa 1-450)

VAng-Lsx06178-500gEcoli 500 µg (E. coli)
EUR 3569
Description: Mycoplasma Capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) Chromosomal replication initiator protein DnaA, recombinant protein.

Recombinant Mycoplasma Capricolum dnaA Protein (aa 1-450)

VAng-Lsx06178-50gEcoli 50 µg (E. coli)
EUR 2443
Description: Mycoplasma Capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) Chromosomal replication initiator protein DnaA, recombinant protein.

Recombinant Bordetella Parapertussis mnmE Protein (aa 1-450)

VAng-Lsx4585-1mgEcoli 1 mg (E. coli)
EUR 5303
Description: Bordetella Parapertussis tRNA modification GTPase MnmE, recombinant protein.

Recombinant Bordetella Parapertussis mnmE Protein (aa 1-450)

VAng-Lsx4585-500gEcoli 500 µg (E. coli)
EUR 3583
Description: Bordetella Parapertussis tRNA modification GTPase MnmE, recombinant protein.

Recombinant Bordetella Parapertussis mnmE Protein (aa 1-450)

VAng-Lsx4585-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Bordetella Parapertussis tRNA modification GTPase MnmE, recombinant protein.

Recombinant Shigella Boydii wzyE Protein (aa 1-450)

VAng-Lsx09446-inquire inquire Ask for price
Description: Shigella Boydii serotype 4 (strain Sb227) Putative ECA polymerase, recombinant protein.

Recombinant Clostridium Acetobutylicum pgi Protein (aa 1-450)

VAng-Lsx7733-1mgEcoli 1 mg (E. coli)
EUR 5303
Description: Clostridium Acetobutylicum Glucose-6-phosphate isomerase, recombinant protein.

Recombinant Clostridium Acetobutylicum pgi Protein (aa 1-450)

VAng-Lsx7733-500gEcoli 500 µg (E. coli)
EUR 3583
Description: Clostridium Acetobutylicum Glucose-6-phosphate isomerase, recombinant protein.

Recombinant Clostridium Acetobutylicum pgi Protein (aa 1-450)

VAng-Lsx7733-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Clostridium Acetobutylicum Glucose-6-phosphate isomerase, recombinant protein.

Recombinant Mouse AMH Protein (aa 450-552) (Yeast)

VAng-3013Lsx-1mg 1 mg
EUR 4807
Description: Recombinant Mouse AMH protein was expressed in yeast (Uniprot ID: P27106)

Recombinant Mouse AMH Protein (aa 450-552) (Yeast)

VAng-3013Lsx-200g 200 µg
EUR 1920
Description: Recombinant Mouse AMH protein was expressed in yeast (Uniprot ID: P27106)

Recombinant Mouse AMH Protein (aa 450-552) (Yeast)

VAng-3013Lsx-500g 500 µg
EUR 3129
Description: Recombinant Mouse AMH protein was expressed in yeast (Uniprot ID: P27106)

Recombinant Pasteurella Multocida PM0878 Protein (aa 1-450)

VAng-Cr7120-1mgEcoli 1 mg (E. coli)
EUR 5054
Description: Pasteurella Multocida (strain Pm70) Deoxyguanosinetriphosphate triphosphohydrolase-like protein (PM0878), recombinant protein.

Recombinant Pasteurella Multocida PM0878 Protein (aa 1-450)

VAng-Cr7120-500gEcoli 500 µg (E. coli)
EUR 3569
Description: Pasteurella Multocida (strain Pm70) Deoxyguanosinetriphosphate triphosphohydrolase-like protein (PM0878), recombinant protein.

Recombinant Pasteurella Multocida PM0878 Protein (aa 1-450)

VAng-Cr7120-50gEcoli 50 µg (E. coli)
EUR 2443
Description: Pasteurella Multocida (strain Pm70) Deoxyguanosinetriphosphate triphosphohydrolase-like protein (PM0878), recombinant protein.

Recombinant Shigella Sonnei wzyE Protein (aa 1-450)

VAng-0304Lsx-inquire inquire Ask for price
Description: Shigella Sonnei (strain Ss046) Putative ECA polymerase, recombinant protein.

Recombinant Treponema Pallidum TP_0600 Protein (aa 1-450)

VAng-Cr1387-inquire inquire Ask for price
Description: Treponema Pallidum (strain Nichols) putative zinc metalloprotease TP_0600 (TP_0600), recombinant protein.

Recombinant Mycoplasma Pneumoniae ffh Protein (aa 1-450)

VAng-Lsx04718-1mgEcoli 1 mg (E. coli)
EUR 5054
Description: Mycoplasma Pneumoniae (strain ATCC 29342 / M129) Signal recognition particle protein, recombinant protein.

Recombinant Mycoplasma Pneumoniae ffh Protein (aa 1-450)

VAng-Lsx04718-50gEcoli 50 µg (E. coli)
EUR 2443
Description: Mycoplasma Pneumoniae (strain ATCC 29342 / M129) Signal recognition particle protein, recombinant protein.

Recombinant Streptococcus Agalactiae glmM Protein (aa 1-450)

VAng-Cr7495-1mgEcoli 1 mg (E. coli)
EUR 5054
Description: Streptococcus Agalactiae serotype Ia Phosphoglucosamine mutase (glmM), recombinant protein.

Recombinant Streptococcus Agalactiae glmM Protein (aa 1-450)

VAng-Cr7495-500gEcoli 500 µg (E. coli)
EUR 3569
Description: Streptococcus Agalactiae serotype Ia Phosphoglucosamine mutase (glmM), recombinant protein.

Recombinant Streptococcus Agalactiae glmM Protein (aa 1-450)

VAng-Cr7495-50gEcoli 50 µg (E. coli)
EUR 2443
Description: Streptococcus Agalactiae serotype Ia Phosphoglucosamine mutase (glmM), recombinant protein.

Recombinant Streptococcus Thermophilus gor Protein (aa 1-450)

VAng-Cr8420-1mgEcoli 1 mg (E. coli)
EUR 5054
Description: Streptococcus Thermophilus Glutathione reductase (gor), recombinant protein.

Recombinant Streptococcus Thermophilus gor Protein (aa 1-450)

VAng-Cr8420-500gEcoli 500 µg (E. coli)
EUR 3569
Description: Streptococcus Thermophilus Glutathione reductase (gor), recombinant protein.

Recombinant Streptococcus Thermophilus gor Protein (aa 1-450)

VAng-Cr8420-50gEcoli 50 µg (E. coli)
EUR 2443
Description: Streptococcus Thermophilus Glutathione reductase (gor), recombinant protein.

Recombinant Clostridium Novyi pgi Protein (aa 1-450)

VAng-Lsx00068-1mgEcoli 1 mg (E. coli)
EUR 5303
Description: Clostridium Novyi (strain NT) Glucose-6-phosphate isomerase, recombinant protein.

Recombinant Clostridium Novyi pgi Protein (aa 1-450)

VAng-Lsx00068-500gEcoli 500 µg (E. coli)
EUR 3583
Description: Clostridium Novyi (strain NT) Glucose-6-phosphate isomerase, recombinant protein.

Recombinant Clostridium Novyi pgi Protein (aa 1-450)

VAng-Lsx00068-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Clostridium Novyi (strain NT) Glucose-6-phosphate isomerase, recombinant protein.

Recombinant Clostridium Perfringens CPE1497 Protein (aa 1-450)

VAng-Lsx00378-1mgEcoli 1 mg (E. coli)
EUR 5303
Description: Clostridium Perfringens UPF0210 protein CPE1497, recombinant protein.

Recombinant Clostridium Perfringens CPE1497 Protein (aa 1-450)

VAng-Lsx00378-500gEcoli 500 µg (E. coli)
EUR 3583
Description: Clostridium Perfringens UPF0210 protein CPE1497, recombinant protein.

Recombinant Clostridium Perfringens CPE1497 Protein (aa 1-450)

VAng-Lsx00378-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Clostridium Perfringens UPF0210 protein CPE1497, recombinant protein.

Recombinant Clostridium Perfringens CPF_1748 Protein (aa 1-450)

VAng-Lsx00411-1mgEcoli 1 mg (E. coli)
EUR 5303
Description: Clostridium Perfringens (strain ATCC 13124 / NCTC 8237 / Type A) UPF0210 protein CPF_1748, recombinant protein.

Recombinant Clostridium Perfringens CPF_1748 Protein (aa 1-450)

VAng-Lsx00411-500gEcoli 500 µg (E. coli)
EUR 3583
Description: Clostridium Perfringens (strain ATCC 13124 / NCTC 8237 / Type A) UPF0210 protein CPF_1748, recombinant protein.

Recombinant Clostridium Perfringens CPF_1748 Protein (aa 1-450)

VAng-Lsx00411-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Clostridium Perfringens (strain ATCC 13124 / NCTC 8237 / Type A) UPF0210 protein CPF_1748, recombinant protein.

Recombinant Clostridium Perfringens pgi Protein (aa 1-450)

VAng-Lsx00638-1mgEcoli 1 mg (E. coli)
EUR 5303
Description: Clostridium Perfringens Glucose-6-phosphate isomerase, recombinant protein.

Recombinant Clostridium Perfringens pgi Protein (aa 1-450)

VAng-Lsx00638-500gEcoli 500 µg (E. coli)
EUR 3583
Description: Clostridium Perfringens Glucose-6-phosphate isomerase, recombinant protein.

Recombinant Clostridium Perfringens pgi Protein (aa 1-450)

VAng-Lsx00638-50gEcoli 50 µg (E. coli)
EUR 2437
Description: Clostridium Perfringens Glucose-6-phosphate isomerase, recombinant protein.

Recombinant Clostridium Symbiosum gdh Protein (aa 2-450)

VAng-Lsx01507-1mgEcoli 1 mg (E. coli)
EUR 5058
Description: Clostridium Symbiosum NAD-specific glutamate dehydrogenase, recombinant protein.

Recombinant Clostridium Symbiosum gdh Protein (aa 2-450)

VAng-Lsx01507-500gEcoli 500 µg (E. coli)
EUR 3572
Description: Clostridium Symbiosum NAD-specific glutamate dehydrogenase, recombinant protein.
  1. Within the following, alizarin pink, oil red-O and toluidine blue staining have been carried out to judge the multi-lineage differentiation of zebrafish coronary heart and liver tissue-derived MSCs. Subsequently, the gene and protein expression of Oct4, Sox2 and Nanog as pluri

    -potent markers have been analyzed by RT-PCR and western blotting, respectively.

As well as, MTT assay was used for cell proliferation potential and inhabitants doubling time (PDT) evaluation. Additionally, the growing older of cells was investigated by β-galactosidase exercise assay. The outcomes confirmed that, like different MSCs, zebrafish coronary heart and liver tissue-derived MSCs have been constructive for mesenchymal, adverse for hematopoietic markers and expressed pluripotent markers Oct4, Sox2 and Nanog. Furthermore, these cells have been differentiated to osteocyte, adipocyte, and chondrocyte lineages following directed differentiation. It was discovered that PDT of zebrafish coronary heart and liver tissue-derived MSCs have been 50.67 and 46.61 h, respectively.

These cells had considerably extra speedy progress on day 4. Our outcomes present that zebrafish coronary heart and liver tissue-derived MSCs exhibited typical MSC traits together with fibroblast morphology, multi-lineage differentiation capability, pluriefficiency potential and expression of a typical set of basic MSC floor markers.

Safety and Activity of Metronomic Temozolomide in Second-Line Treatment of Advanced Neuroendocrine Neoplasms.

Safety and Activity of Metronomic Temozolomide in Second-Line Treatment of Advanced Neuroendocrine Neoplasms.

Platinum-based chemotherapy is the mainstay of front-line therapy of sufferers affected by pluri-metastatic intermediate/excessive grade NeuroEndocrine Neoplasms (NENs). Nevertheless, there aren’t any commonplace second-line remedies at illness development.

Earlier scientific experiences have evidenced that temozolomide (TMZ), an oral analog of dacarbazine, is lively in opposition to NENs at commonplace doses of 150 to 200 mg/mq per day on days 1 to five of a 28-day cycle, even when a major treatment-related toxicity is reported.

METHODS

Metastatic NENs sufferers had been handled on the ENETS (European NeuroEndocrine Tumor Society) heart of excellence of Naples (Italy), from 2014 to 2017 with a second-line various metronomic schedule of TMZ, 75 mg/m2per os “one week on/one week off”. Toxicity was graded with NCI-CTC standards v4.0; goal responses with RECIST v1.1 and efficiency standing (PS) in accordance with ECOG.

Twenty-six consecutive sufferers had been handled. Median age was 65.5 years. The predominant main organs had been pancreas and lung. Grading was G2 in 11 sufferers, G3 in 15. Greater than half of sufferers had a PS 2 (15 vs. 11 with PS 1). The median time-on-temozolomide remedy was 12.2 months (95% CI: 11.4-19.6). No G3/G4 toxicities had been registered.

Full response was obtained in 1 affected person, partial response in 4, steady illness in 19 (illness management price: 92.3%), and progressive illness in 2. The median total survival from TMZ begin was 28.Three months. PS improved in 73% of sufferers.Metronomic TMZ is an acceptable therapy for G2 and G3 NENs significantly in PS 2 sufferers. Potential and bigger trials are wanted to verify these outcomes.

Safety and Activity of Metronomic Temozolomide in Second-Line Treatment of Advanced Neuroendocrine Neoplasms.
Security and Exercise of Metronomic Temozolomide in Second-Line Remedy of Superior Neuroendocrine Neoplasms.

Would ivermectin for malaria management be useful in onchocerciasis-endemic areas?

There may be accumulating proof supporting using ivermectin as a malaria management software. Latest findings from the repeat ivermectin mass drug administrations for management of malaria trial demonstrated a diminished incidence of malaria in villages which obtained repeated ivermectin mass drug administration (MDA; six doses) in comparison with those that had just one spherical of ivermectin.

EEF1A2 siRNA

20-abx901643
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

EEF1A2 Antibody

1-CSB-PA007412ESR1HU
  • EUR 222.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against EEF1A2. Recognizes EEF1A2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

EEF1A2 Antibody

1-CSB-PA007412ESR2HU
  • EUR 222.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against EEF1A2. Recognizes EEF1A2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

EEF1A2 Antibody

1-CSB-PA007412GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
Description: A polyclonal antibody against EEF1A2. Recognizes EEF1A2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

EEF1A2 Antibody

45965-100ul 100ul
EUR 252

EEF1A2 Antibody

45965-50ul 50ul
EUR 187

EEF1A2 Antibody

DF9493 200ul
EUR 304
Description: EEF1A2 Antibody detects endogenous levels of total EEF1A2.

EEF1A2 Antibody

ABD9493 100 ug
EUR 438

pOTB7-EEF1A2

PVT18428 2 ug
EUR 231

EEF1A2 antibody

70R-17001 50 ul
EUR 435
Description: Rabbit polyclonal EEF1A2 antibody

EEF1A2 antibody

70R-3046 50 ug
EUR 467
Description: Rabbit polyclonal EEF1A2 antibody raised against the middle region of EEF1A2

EEF1A2 Peptide

43-205P 0.1 mg
EUR 338

EEF1A2 Rabbit pAb

A2473-100ul 100 ul
EUR 308

EEF1A2 Rabbit pAb

A2473-200ul 200 ul
EUR 459

EEF1A2 Rabbit pAb

A2473-20ul 20 ul
EUR 183

EEF1A2 Rabbit pAb

A2473-50ul 50 ul
EUR 223

Anti-EEF1A2 antibody

STJ11100935 100 µl
EUR 277
Description: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer.

Anti-EEF1A2 antibody

STJ72917 100 µg
EUR 359

EEF1A2 Rabbit pAb

A7327-100ul 100 ul
EUR 308

EEF1A2 Rabbit pAb

A7327-200ul 200 ul
EUR 459

EEF1A2 Rabbit pAb

A7327-20ul 20 ul
EUR 183

EEF1A2 Rabbit pAb

A7327-50ul 50 ul
EUR 223

Human EEF1a2 Protein

20-abx650911
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

anti- EEF1A2 antibody

FNab02642 100µg
EUR 505.25
Description: Antibody raised against EEF1A2

EEF1A2 Conjugated Antibody

C45965 100ul
EUR 397

Recombinant Human EEF1A2

P0565 100ug
EUR 522.36
Description: Recombinant Human protein for EEF1A2

EEF1A2 Blocking Peptide

DF9493-BP 1mg
EUR 195

Anti-EEF1A2 antibody

PAab02642 100 ug
EUR 355

pCMV-SPORT6-EEF1A2

PVT14336 2 ug
EUR 495

EEF1A2 Blocking Peptide

33R-9588 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EEF1A2 antibody, catalog no. 70R-3046

Rat EEF1A2 shRNA Plasmid

20-abx984646
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Human EEF1A2 shRNA Plasmid

20-abx951333
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Mouse EEF1A2 shRNA Plasmid

20-abx970114
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Anti-eEF1A2 (Ser358) antibody

STJ120062 100 µl
EUR 526

EEF1A1 / EEF1A2 / EEF1A1P5 Antibody

20-abx327705
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

EEF1A1/EEF1A2/EEF1A1P5 Antibody

1-CSB-PA005918
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EEF1A1/EEF1A2/EEF1A1P5. Recognizes EEF1A1/EEF1A2/EEF1A1P5 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

EEF1A2 ELISA KIT|Human

EF009296 96 Tests
EUR 689

EEF1A2 Recombinant Protein (Mouse)

RP130898 100 ug Ask for price

EEF1A2 Recombinant Protein (Rat)

RP199082 100 ug Ask for price

EEF1A2 Recombinant Protein (Human)

RP010195 100 ug Ask for price

eEF1A2 binding protein Polyclonal Antibody

ES8281-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/Rat/Mouse/Pig. This antibody is tested and validated for WB, ELISA, IHC

eEF1A2 binding protein Polyclonal Antibody

ES8281-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/Rat/Mouse/Pig. This antibody is tested and validated for WB, ELISA, IHC

Anti-Phospho-eEF1A2 (Ser358) Antibody

P03304 100ul
EUR 398
Description: Rabbit Polyclonal Phospho-eEF1A2 (Ser358) Antibody. Validated in WB and tested in Mouse.

eEF1A2 binding protein Polyclonal Antibody

EA194-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/ Rat/ Mouse/ Pg. This antibody is tested and validated for WB, ELISA, IHC

eEF1A2 binding protein Polyclonal Antibody

EA194-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/ Rat/ Mouse/ Pg. This antibody is tested and validated for WB, ELISA, IHC

eEF1A2 binding protein Polyclonal Antibody

EA252-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/ Rat/ Mouse/ Pig. This antibody is tested and validated for WB, ELISA, IHC

eEF1A2 binding protein Polyclonal Antibody

EA252-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/ Rat/ Mouse/ Pig. This antibody is tested and validated for WB, ELISA, IHC

Anti-eEF1A2 binding protein Antibody

A14038 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for eEF1A2 binding protein Antibody (IGFN1) detection. Tested with WB, IHC in Human, Mouse, Rat, Pig.

eEF1A2 binding protein Polyclonal Antibody

ABP57282-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of eEF1A2 binding protein from Human, Mouse, Rat, Pig. This eEF1A2 binding protein antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

eEF1A2 binding protein Polyclonal Antibody

ABP57282-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of eEF1A2 binding protein from Human, Mouse, Rat, Pig. This eEF1A2 binding protein antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

eEF1A2 binding protein Polyclonal Antibody

ABP57282-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of eEF1A2 binding protein from Human, Mouse, Rat, Pig. This eEF1A2 binding protein antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

Anti-eEF1A2 binding protein antibody

STJ97490 200 µl
EUR 197
Description: Rabbit polyclonal to eEF1A2 binding protein.

anti-eEF1A2 binding protein (5B12)

LF-MA10086 100 ug
EUR 363
Description: Mouse monoclonal to eEF1A2 binding protein

Eef1a2 ORF Vector (Rat) (pORF)

ORF066362 1.0 ug DNA
EUR 506

Eef1a2 ORF Vector (Mouse) (pORF)

ORF043634 1.0 ug DNA
EUR 506

EEF1A2 ORF Vector (Human) (pORF)

ORF003399 1.0 ug DNA
EUR 95

EEF1A2 sgRNA CRISPR Lentivector set (Human)

K0655101 3 x 1.0 ug
EUR 339

Eef1a2 sgRNA CRISPR Lentivector set (Rat)

K6923401 3 x 1.0 ug
EUR 339

Eef1a2 sgRNA CRISPR Lentivector set (Mouse)

K3721701 3 x 1.0 ug
EUR 339

EEF1A2 sgRNA CRISPR Lentivector (Human) (Target 1)

K0655102 1.0 ug DNA
EUR 154

EEF1A2 sgRNA CRISPR Lentivector (Human) (Target 2)

K0655103 1.0 ug DNA
EUR 154

EEF1A2 sgRNA CRISPR Lentivector (Human) (Target 3)

K0655104 1.0 ug DNA
EUR 154

Eef1a2 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6923402 1.0 ug DNA
EUR 154

Eef1a2 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6923403 1.0 ug DNA
EUR 154

Eef1a2 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6923404 1.0 ug DNA
EUR 154

Eef1a2 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3721702 1.0 ug DNA
EUR 154

Eef1a2 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3721703 1.0 ug DNA
EUR 154

Eef1a2 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3721704 1.0 ug DNA
EUR 154

Eef1a2 3'UTR GFP Stable Cell Line

TU253788 1.0 ml Ask for price

Eef1a2 3'UTR Luciferase Stable Cell Line

TU203788 1.0 ml Ask for price

Eef1a2 3'UTR GFP Stable Cell Line

TU155610 1.0 ml Ask for price

Eef1a2 3'UTR Luciferase Stable Cell Line

TU105610 1.0 ml Ask for price

EEF1A2 3'UTR Luciferase Stable Cell Line

TU006615 1.0 ml
EUR 1394

EEF1A2 3'UTR GFP Stable Cell Line

TU056615 1.0 ml
EUR 1394

EEF1A2 Protein Vector (Human) (pPB-C-His)

PV013593 500 ng
EUR 329

EEF1A2 Protein Vector (Human) (pPB-N-His)

PV013594 500 ng
EUR 329

EEF1A2 Protein Vector (Human) (pPM-C-HA)

PV013595 500 ng
EUR 329

EEF1A2 Protein Vector (Human) (pPM-C-His)

PV013596 500 ng
EUR 329

EEF1A2 Protein Vector (Mouse) (pPB-C-His)

PV174534 500 ng
EUR 603

EEF1A2 Protein Vector (Mouse) (pPB-N-His)

PV174535 500 ng
EUR 603

EEF1A2 Protein Vector (Mouse) (pPM-C-HA)

PV174536 500 ng
EUR 603

EEF1A2 Protein Vector (Mouse) (pPM-C-His)

PV174537 500 ng
EUR 603

EEF1A2 Protein Vector (Rat) (pPB-C-His)

PV265446 500 ng
EUR 603

EEF1A2 Protein Vector (Rat) (pPB-N-His)

PV265447 500 ng
EUR 603

EEF1A2 Protein Vector (Rat) (pPM-C-HA)

PV265448 500 ng
EUR 603

EEF1A2 Protein Vector (Rat) (pPM-C-His)

PV265449 500 ng
EUR 603

EEF1A2 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV678607 1.0 ug DNA
EUR 682

EEF1A2 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV678611 1.0 ug DNA
EUR 682

EEF1A2 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV678612 1.0 ug DNA
EUR 682

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

20-abx126892
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

20-abx112350
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

abx026885-400ul 400 ul
EUR 523

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

abx026885-80l 80 µl
EUR 286

Human Elongation Factor 1 Alpha 2 (EEF1A2) ELISA Kit

abx387052-96tests 96 tests
EUR 911

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

abx431222-200ul 200 ul
EUR 384

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

20-abx321863
  • EUR 439.00
  • EUR 328.00
  • 100 ul
  • 50 ul

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

20-abx321864
  • EUR 439.00
  • EUR 328.00
  • 100 ul
  • 50 ul

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

20-abx225152
  • EUR 370.00
  • EUR 606.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul

A number of different research investigating the advantages of ivermectin for malaria functions are ongoing/deliberate.Whereas ivermectin MDA provides promising views within the combat in opposition to malaria, we spotlight the added advantages and anticipated challenges of conducting future research in onchocerciasis-endemic areas, that are confronted with a considerable illness burden together with onchocerciasis-associated epilepsy.

Rising the frequency of ivermectin MDA in such locations could scale back the burden of each malaria and onchocerciasis, and permit for extra entomological investigations on each the Anopheles mosquitoes and the blackflies.

Upfront, acceptability and feasibility research are wanted to evaluate the endorsement by the native populations, in addition to the programmatic feasibility of implementing ivermectin MDA a number of occasions a yr.Onchocerciasis-endemic websites would doubly profit from ivermectin MDA interventions, as these will alleviate onchocerciasis-associated morbidity and mortality, whereas doubtlessly curbing malaria transmission. Involving onchocerciasis applications and different related stakeholders within the malaria/ivermectin analysis agenda would foster the implementation of pluri-annual MDA in goal communities.

The ZT Biopolymer: A Self-Assembling Protein Scaffold for Stem Cell Applications.

The ZT Biopolymer: A Self-Assembling Protein Scaffold for Stem Cell Applications.

The event of cell tradition programs for the naturalistic propagation, self-renewal and differentiation of cells ex vivo is a excessive purpose of molecular engineering. Regardless of vital success in recent times, the excessive value of up-scaling cultures, the necessity for xeno-free tradition situations, and the diploma of mimicry of the natural extracellular matrix attainable in vitro utilizing designer substrates proceed to pose obstacles to the interpretation of cell-based technologies.

On this regard, the ZT biopolymer is a protein-based, steady, scalable, and economical cell substrate of excessive promise. ZT relies on the naturally occurring meeting of two human proteins: titin-Z1Z2 and telethonin. These protein constructing blocks are strong scaffolds that may be conveniently functionalized with full-length proteins and bioactive peptidic motifs by genetic manipulation, previous to self-assembly.

The polymer is, thereby, totally encodable. Functionalized variations of the ZT polymer have been proven to efficiently maintain the long-term culturing of human embryonic stem cells (hESCs), human induced pluripotent stem cells (hiPSCs), and murine mesenchymal stromal cells (mMSCs).

Pluripotency of hESCs and hiPSCs was retained for the longest interval assayed (four months). Outcomes level to the big potential of the ZT system for the creation of a modular, pluri-functional biomaterial for cell-based purposes.

The ZT Biopolymer: A Self-Assembling Protein Scaffold for Stem Cell Applications.

Maxwell®: An Unsupervised Studying Method for 5P Medication.

Within the 5P medication (Customized, Preventive, Participative, Predictive and Pluri-expert), the final pattern is to course of information by displacing the barycenter of the data from hospital centered programs to the affected person centered ones by his private medical information.

Human Epidermal Growth Factor (EGF) ELISA Kit

DLR-EGF-Hu-48T 48T
EUR 317
Description: A sandwich quantitative ELISA assay kit for detection of Human Epidermal Growth Factor (EGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Epidermal Growth Factor (EGF) ELISA Kit

DLR-EGF-Hu-96T 96T
EUR 398
Description: A sandwich quantitative ELISA assay kit for detection of Human Epidermal Growth Factor (EGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Epidermal Growth Factor (EGF) ELISA Kit

DLR-EGF-Mu-48T 48T
EUR 315
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Epidermal Growth Factor (EGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Epidermal Growth Factor (EGF) ELISA Kit

DLR-EGF-Mu-96T 96T
EUR 396
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Epidermal Growth Factor (EGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Epidermal Growth Factor (EGF) ELISA Kit

DLR-EGF-p-48T 48T
EUR 493
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Epidermal Growth Factor (EGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Epidermal Growth Factor (EGF) ELISA Kit

DLR-EGF-p-96T 96T
EUR 641
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Epidermal Growth Factor (EGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Epidermal Growth Factor (EGF) ELISA Kit

DLR-EGF-Ra-48T 48T
EUR 372
Description: A sandwich quantitative ELISA assay kit for detection of Rat Epidermal Growth Factor (EGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Epidermal Growth Factor (EGF) ELISA Kit

DLR-EGF-Ra-96T 96T
EUR 475
Description: A sandwich quantitative ELISA assay kit for detection of Rat Epidermal Growth Factor (EGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Epidermal Growth Factor (EGF) ELISA Kit

RD-EGF-Hu-48Tests 48 Tests
EUR 295

Human Epidermal Growth Factor (EGF) ELISA Kit

RD-EGF-Hu-96Tests 96 Tests
EUR 400

Mouse Epidermal Growth Factor (EGF) ELISA Kit

RD-EGF-Mu-48Tests 48 Tests
EUR 293

Mouse Epidermal Growth Factor (EGF) ELISA Kit

RD-EGF-Mu-96Tests 96 Tests
EUR 398

Porcine Epidermal Growth Factor (EGF) ELISA Kit

RD-EGF-p-48Tests 48 Tests
EUR 494

Porcine Epidermal Growth Factor (EGF) ELISA Kit

RD-EGF-p-96Tests 96 Tests
EUR 684

Rat Epidermal Growth Factor (EGF) ELISA Kit

RD-EGF-Ra-48Tests 48 Tests
EUR 358

Rat Epidermal Growth Factor (EGF) ELISA Kit

RD-EGF-Ra-96Tests 96 Tests
EUR 490

Human Epidermal Growth Factor (EGF) ELISA Kit

RDR-EGF-Hu-48Tests 48 Tests
EUR 307

Human Epidermal Growth Factor (EGF) ELISA Kit

RDR-EGF-Hu-96Tests 96 Tests
EUR 418

Mouse Epidermal Growth Factor (EGF) ELISA Kit

RDR-EGF-Mu-48Tests 48 Tests
EUR 305

Mouse Epidermal Growth Factor (EGF) ELISA Kit

RDR-EGF-Mu-96Tests 96 Tests
EUR 415

Porcine Epidermal Growth Factor (EGF) ELISA Kit

RDR-EGF-p-48Tests 48 Tests
EUR 516

Porcine Epidermal Growth Factor (EGF) ELISA Kit

RDR-EGF-p-96Tests 96 Tests
EUR 716

Rat Epidermal Growth Factor (EGF) ELISA Kit

RDR-EGF-Ra-48Tests 48 Tests
EUR 374

Rat Epidermal Growth Factor (EGF) ELISA Kit

RDR-EGF-Ra-96Tests 96 Tests
EUR 512

EGF

E13-007-1 10μg
EUR 83

EGF

E13-007-2 50μg
EUR 115

EGF

E21-029 10ug
EUR 343

EGF

MO15063 100 ug
EUR 409

EGF

PR27006 500 ug
EUR 318

EGF

PR27009 500 ug
EUR 318

EGF

LF-PR003 200 ug
EUR 142
Description: EGF protein

EGF, Rat

HY-P7092 50ug
EUR 211

EGF, Mouse

HY-P7067 100ug
EUR 187

EGF, Human

HY-P7109 50ug
EUR 108

His-EGF

E13-006-1 10μg
EUR 83

His-EGF

E13-006-2 50μg
EUR 115

EGF Protein

abx069820-1mg 1 mg
EUR 1080

EGF Protein

abx169012-1mg 1 mg
EUR 453

EGF siRNA

20-abx915073
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

EGF siRNA

20-abx915074
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

EGF Antibody

35720-100ul 100ul
EUR 252

EGF antibody

38447-100ul 100ul
EUR 252

EGF siRNA

20-abx901657
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

EGF Pichia

PR27007 500 ug
EUR 318

ISOKine-EGF

PR80002 100 ug
EUR 344

EGF Antibody

1-CSB-PA06244A0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGF. Recognizes EGF from Human. This antibody is Unconjugated. Tested in the following application: ELISA

egf Antibody

1-CSB-PA24449A0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against egf. Recognizes egf from Zebrafish. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:5000

EGF Antibody

1-CSB-PA007939
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGF. Recognizes EGF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000

EGF Antibody

1-CSB-PA942209
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against EGF. Recognizes EGF from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:50-1:200

EGF Antibody

1-CSB-PA846755
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against EGF. Recognizes EGF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

EGF Mouse

P2558-.1 100 µg
EUR 108

EGF Mouse

P2558-.5 500 µg
EUR 200

EGF Mouse

P2558-1 1 mg
EUR 311

EGF Antibody

49545-100ul 100ul
EUR 333

EGF Antibody

49545-50ul 50ul
EUR 239

EGF Antibody

DF2225 200ul
EUR 304
Description: EGF antibody detects endogenous levels of total EGF.

rHu EGF

AK8327-0100 100µg Ask for price

rHu EGF

AK8327-0500 500µg Ask for price

rHu EGF

AK8327-1000 1mg Ask for price

EGF Antibody

BF0066 200ul
EUR 376
Description: EGF antibody detects endogenous levels of total EGF.

EGF Antibody

AF5148 200ul
EUR 304
Description: EGF Antibody detects endogenous levels of total EGF.

EGF Antibody

DF7063 200ul
EUR 304
Description: EGF Antibody detects endogenous levels of total EGF.

EGF Antibody

ABD2225 100 ug
EUR 438

EGF Antibody

ABD7063 100 ug
EUR 438

EGF Antibody

ABF5148 100 ug
EUR 438

EGF Antibody

5022-100
EUR 316

EGF Antibody

5022-30T
EUR 146

EGF Antibody

5023R-100
EUR 316

EGF Antibody

5023R-30T
EUR 146

anti-EGF

YF-PA23628 50 ul
EUR 334
Description: Mouse polyclonal to EGF

EGF antibody

10R-2038 100 ul
EUR 403
Description: Mouse monoclonal EGF antibody

EGF antibody

10R-2176 100 ul
EUR 403
Description: Mouse monoclonal EGF antibody

EGF antibody

10R-2969 100 ug
EUR 265
Description: Mouse monoclonal EGF antibody

EGF antibody

10R-2985 100 ug
EUR 265
Description: Mouse monoclonal EGF antibody

EGF antibody

20R-1772 100 ug
EUR 673
Description: Rabbit polyclonal EGF antibody

EGF antibody

70R-15294 100 ug
EUR 327
Description: Rabbit polyclonal EGF antibody

EGF antibody

10-E39A 500 ug
EUR 566
Description: Mouse monoclonal EGF antibody

EGF antibody

70-ER40 50 ug
EUR 284
Description: Affinity purified Rabbit polyclonal EGF antibody

EGF antibody

10R-7766 500 ug
EUR 565
Description: Mouse monoclonal EGF antibody

EGF antibody

20C-CR1085GP 100 ug
EUR 148
Description: Goat polyclonal EGF antibody

EGF antibody

70R-5697 50 ug
EUR 467
Description: Rabbit polyclonal EGF antibody

EGF antibody

70R-EG001 50 ug
EUR 273
Description: Affinity purified Goat polyclonal EGF antibody

EGF antibody

70R-ER012 50 ug
EUR 273
Description: Affinity purified Rabbit polyclonal EGF antibody

EGF protein

30R-1056 100 ug
EUR 268
Description: Purified recombinant Human EGF protein

EGF protein

30R-2331 500 ug
EUR 317
Description: Purified recombinant Human EGF protein

EGF protein

30R-2332 500 ug
EUR 325
Description: Purified recombinant Mouse EGF protein

EGF protein

30R-2333 20 ug
EUR 210
Description: Purified recombinant Rat EGF protein

EGF protein

30R-AE003 1 mg
EUR 381
Description: Purified recombinant Human EGF protein

EGF protein

30R-AE004 100 ug
EUR 133
Description: Purified recombinant Human EGF protein

EGF protein

30R-AE025 100 ug
EUR 273
Description: Purified recombinant Human EGF protein

EGF antibody

70R-12248 100 ug
EUR 403
Description: Rabbit polyclonal EGF antibody

EGF antibody

70R-12249 100 ug
EUR 403
Description: Rabbit polyclonal EGF antibody

EGF antibody

70R-13940 100 ug
EUR 322
Description: Affinity purified Goat polyclonal EGF antibody

HB-EGF/ Rat HB- EGF ELISA Kit

ELA-E1479r 96 Tests
EUR 886

HB-EGF, Human

HY-P7017 100ug
EUR 360

HB-EGF, Mouse

HY-P7194 50ug
EUR 268

EGF Polyclonal Antibody

ES5049-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against EGF from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

EGF Polyclonal Antibody

ES5049-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against EGF from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

In the present day, using synthetic intelligence for supporting this transition exhibits actual limitations in its implementation in operational follow, each on the stage of affected person care, but in addition within the basic each day lifetime of the well being skilled, due to the medico-legal imperatives induced by the guarantees of the ‘5P medication’.

On this paper, we suggest to fill this hole by introducing an authentic synthetic intelligence platform, named Maxwell, which follows an unsupervised studying method consistent with the medico-legal imperatives of the ‘5P medication’. We describe the useful platform traits and illustrate them by two examples of clustering in genomics and magnetic resonance imaging.