Safety and Activity of Metronomic Temozolomide in Second-Line Treatment of Advanced Neuroendocrine Neoplasms.

Safety and Activity of Metronomic Temozolomide in Second-Line Treatment of Advanced Neuroendocrine Neoplasms.

Platinum-based chemotherapy is the mainstay of front-line therapy of sufferers affected by pluri-metastatic intermediate/excessive grade NeuroEndocrine Neoplasms (NENs). Nevertheless, there aren’t any commonplace second-line remedies at illness development.

Earlier scientific experiences have evidenced that temozolomide (TMZ), an oral analog of dacarbazine, is lively in opposition to NENs at commonplace doses of 150 to 200 mg/mq per day on days 1 to five of a 28-day cycle, even when a major treatment-related toxicity is reported.

METHODS

Metastatic NENs sufferers had been handled on the ENETS (European NeuroEndocrine Tumor Society) heart of excellence of Naples (Italy), from 2014 to 2017 with a second-line various metronomic schedule of TMZ, 75 mg/m2per os “one week on/one week off”. Toxicity was graded with NCI-CTC standards v4.0; goal responses with RECIST v1.1 and efficiency standing (PS) in accordance with ECOG.

Twenty-six consecutive sufferers had been handled. Median age was 65.5 years. The predominant main organs had been pancreas and lung. Grading was G2 in 11 sufferers, G3 in 15. Greater than half of sufferers had a PS 2 (15 vs. 11 with PS 1). The median time-on-temozolomide remedy was 12.2 months (95% CI: 11.4-19.6). No G3/G4 toxicities had been registered.

Full response was obtained in 1 affected person, partial response in 4, steady illness in 19 (illness management price: 92.3%), and progressive illness in 2. The median total survival from TMZ begin was 28.Three months. PS improved in 73% of sufferers.Metronomic TMZ is an acceptable therapy for G2 and G3 NENs significantly in PS 2 sufferers. Potential and bigger trials are wanted to verify these outcomes.

Safety and Activity of Metronomic Temozolomide in Second-Line Treatment of Advanced Neuroendocrine Neoplasms.
Security and Exercise of Metronomic Temozolomide in Second-Line Remedy of Superior Neuroendocrine Neoplasms.

Would ivermectin for malaria management be useful in onchocerciasis-endemic areas?

There may be accumulating proof supporting using ivermectin as a malaria management software. Latest findings from the repeat ivermectin mass drug administrations for management of malaria trial demonstrated a diminished incidence of malaria in villages which obtained repeated ivermectin mass drug administration (MDA; six doses) in comparison with those that had just one spherical of ivermectin.

EEF1A2 antibody

70R-17001 50 ul
EUR 522
Description: Rabbit polyclonal EEF1A2 antibody

EEF1A2 Antibody

45965-100ul 100ul
EUR 302.4

EEF1A2 Antibody

45965-50ul 50ul
EUR 224.4

EEF1A2 Antibody

ABD9493 100 ug
EUR 525.6

EEF1A2 siRNA

20-abx901643
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EEF1A2 siRNA

20-abx914976
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EEF1A2 siRNA

20-abx914977
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EEF1A2 Antibody

AF6618 100ul
EUR 420

EEF1A2 Antibody

1-CSB-PA007412ESR1HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against EEF1A2. Recognizes EEF1A2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

EEF1A2 Antibody

1-CSB-PA007412ESR2HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against EEF1A2. Recognizes EEF1A2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

EEF1A2 Antibody

1-CSB-PA007412GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against EEF1A2. Recognizes EEF1A2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

EEF1A2 Antibody

DF9493 200ul
EUR 420

pOTB7-EEF1A2

PVT18428 2 ug
EUR 277.2

EEF1A2 Antibody

R34872-100UG 100 ug
EUR 399

EEF1A2 Blocking Peptide

33R-9588 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EEF1A2 antibody, catalog no. 70R-3046

EEF1A2 Rabbit pAb

A2473-100ul 100 ul
EUR 369.6

EEF1A2 Rabbit pAb

A2473-200ul 200 ul
EUR 550.8

EEF1A2 Rabbit pAb

A2473-20ul 20 ul
EUR 219.6

EEF1A2 Rabbit pAb

A2473-50ul 50 ul
EUR 267.6

EEF1A2 Rabbit pAb

A7327-100ul 100 ul
EUR 369.6

EEF1A2 Rabbit pAb

A7327-200ul 200 ul
EUR 550.8

EEF1A2 Rabbit pAb

A7327-20ul 20 ul
EUR 219.6

EEF1A2 Rabbit pAb

A7327-50ul 50 ul
EUR 267.6

Human EEF1a2 Protein

20-abx650911
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

EEF1A2 Conjugated Antibody

C45965 100ul
EUR 476.4

EEF1A2 Blocking Peptide

DF9493-BP 1mg
EUR 234

Anti-EEF1A2 antibody

PAab02642 100 ug
EUR 426

Recombinant Human EEF1A2

P0565 100ug
EUR 626.83
Description: Recombinant Human protein for EEF1A2

anti- EEF1A2 antibody

FNab02642 100µg
EUR 606.3
Description: Antibody raised against EEF1A2

Anti-EEF1A2 antibody

STJ11100935 100 µl
EUR 332.4
Description: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer.

Anti-EEF1A2 antibody

STJ72917 100 µg
EUR 430.8

pCMV-SPORT6-EEF1A2

PVT14336 2 ug
EUR 594

EEF1A1 / EEF1A2 / EEF1A1P5 Antibody

20-abx327705
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Human EEF1A2 shRNA Plasmid

20-abx951333
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Rat EEF1A2 shRNA Plasmid

20-abx984646
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Phospho-EEF1A2 (Ser358) Antibody

AF3618 100ul
EUR 540

Mouse EEF1A2 shRNA Plasmid

20-abx970114
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

EEF1A1/EEF1A2/EEF1A1P5 Antibody

1-CSB-PA005918
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EEF1A1/EEF1A2/EEF1A1P5. Recognizes EEF1A1/EEF1A2/EEF1A1P5 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

EEF1A2 ELISA KIT|Human

EF009296 96 Tests
EUR 826.8

Anti-eEF1A2 (Ser358) antibody

STJ120062 100 µl
EUR 631.2

EEF1A2 Recombinant Protein (Human)

RP010195 100 ug Ask for price

EEF1A2 Recombinant Protein (Rat)

RP199082 100 ug Ask for price

EEF1A2 Recombinant Protein (Mouse)

RP130898 100 ug Ask for price

Anti-eEF1A2 binding protein Antibody

A14038 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for eEF1A2 binding protein Antibody (IGFN1) detection. Tested with WB, IHC in Human, Mouse, Rat, Pig.

eEF1A2 binding protein Polyclonal Antibody

ABP57282-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of eEF1A2 binding protein from Human, Mouse, Rat, Pig. This eEF1A2 binding protein antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

eEF1A2 binding protein Polyclonal Antibody

ABP57282-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of eEF1A2 binding protein from Human, Mouse, Rat, Pig. This eEF1A2 binding protein antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

eEF1A2 binding protein Polyclonal Antibody

ABP57282-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of eEF1A2 binding protein from Human, Mouse, Rat, Pig. This eEF1A2 binding protein antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

Anti-Phospho-eEF1A2 (Ser358) Antibody

P03304 100ul
EUR 477.6
Description: Rabbit Polyclonal Phospho-eEF1A2 (Ser358) Antibody. Validated in WB and tested in Mouse.

Eef1a2 ORF Vector (Rat) (pORF)

ORF066362 1.0 ug DNA
EUR 607.2

EEF1A2 ORF Vector (Human) (pORF)

ORF003399 1.0 ug DNA
EUR 114

Eef1a2 ORF Vector (Mouse) (pORF)

ORF043634 1.0 ug DNA
EUR 607.2

eEF1A2 binding protein Polyclonal Antibody

EA194-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/ Rat/ Mouse/ Pg. This antibody is tested and validated for WB, ELISA, IHC

eEF1A2 binding protein Polyclonal Antibody

EA194-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/ Rat/ Mouse/ Pg. This antibody is tested and validated for WB, ELISA, IHC

eEF1A2 binding protein Polyclonal Antibody

EA252-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/ Rat/ Mouse/ Pig. This antibody is tested and validated for WB, ELISA, IHC

eEF1A2 binding protein Polyclonal Antibody

EA252-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/ Rat/ Mouse/ Pig. This antibody is tested and validated for WB, ELISA, IHC

anti-eEF1A2 binding protein (5B12)

LF-MA10086 100 ug
EUR 435.6
Description: Mouse monoclonal to eEF1A2 binding protein

eEF1A2 binding protein Polyclonal Antibody

ES8281-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/Rat/Mouse/Pig. This antibody is tested and validated for WB, ELISA, IHC

eEF1A2 binding protein Polyclonal Antibody

ES8281-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against eEF1A2 binding protein from Human/Rat/Mouse/Pig. This antibody is tested and validated for WB, ELISA, IHC

Anti-eEF1A2 binding protein antibody

STJ97490 200 µl
EUR 236.4
Description: Rabbit polyclonal to eEF1A2 binding protein.

Eef1a2 sgRNA CRISPR Lentivector set (Rat)

K6923401 3 x 1.0 ug
EUR 406.8

EEF1A2 sgRNA CRISPR Lentivector set (Human)

K0655101 3 x 1.0 ug
EUR 406.8

Eef1a2 sgRNA CRISPR Lentivector set (Mouse)

K3721701 3 x 1.0 ug
EUR 406.8

Eef1a2 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6923402 1.0 ug DNA
EUR 184.8

Eef1a2 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6923403 1.0 ug DNA
EUR 184.8

Eef1a2 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6923404 1.0 ug DNA
EUR 184.8

EEF1A2 sgRNA CRISPR Lentivector (Human) (Target 1)

K0655102 1.0 ug DNA
EUR 184.8

EEF1A2 sgRNA CRISPR Lentivector (Human) (Target 2)

K0655103 1.0 ug DNA
EUR 184.8

EEF1A2 sgRNA CRISPR Lentivector (Human) (Target 3)

K0655104 1.0 ug DNA
EUR 184.8

Eef1a2 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3721702 1.0 ug DNA
EUR 184.8

Eef1a2 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3721703 1.0 ug DNA
EUR 184.8

Eef1a2 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3721704 1.0 ug DNA
EUR 184.8

EEF1A2 Protein Vector (Human) (pPB-C-His)

PV013593 500 ng
EUR 394.8

EEF1A2 Protein Vector (Human) (pPB-N-His)

PV013594 500 ng
EUR 394.8

EEF1A2 Protein Vector (Human) (pPM-C-HA)

PV013595 500 ng
EUR 394.8

EEF1A2 Protein Vector (Human) (pPM-C-His)

PV013596 500 ng
EUR 394.8

EEF1A2 Protein Vector (Mouse) (pPB-C-His)

PV174534 500 ng
EUR 723.6

EEF1A2 Protein Vector (Mouse) (pPB-N-His)

PV174535 500 ng
EUR 723.6

EEF1A2 Protein Vector (Mouse) (pPM-C-HA)

PV174536 500 ng
EUR 723.6

EEF1A2 Protein Vector (Mouse) (pPM-C-His)

PV174537 500 ng
EUR 723.6

EEF1A2 3'UTR Luciferase Stable Cell Line

TU006615 1.0 ml
EUR 1672.8

Eef1a2 3'UTR GFP Stable Cell Line

TU253788 1.0 ml Ask for price

Eef1a2 3'UTR Luciferase Stable Cell Line

TU105610 1.0 ml Ask for price

EEF1A2 3'UTR GFP Stable Cell Line

TU056615 1.0 ml
EUR 1672.8

Eef1a2 3'UTR Luciferase Stable Cell Line

TU203788 1.0 ml Ask for price

Eef1a2 3'UTR GFP Stable Cell Line

TU155610 1.0 ml Ask for price

EEF1A2 Protein Vector (Rat) (pPB-C-His)

PV265446 500 ng
EUR 723.6

EEF1A2 Protein Vector (Rat) (pPB-N-His)

PV265447 500 ng
EUR 723.6

EEF1A2 Protein Vector (Rat) (pPM-C-HA)

PV265448 500 ng
EUR 723.6

EEF1A2 Protein Vector (Rat) (pPM-C-His)

PV265449 500 ng
EUR 723.6

EEF1A2 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV678607 1.0 ug DNA
EUR 818.4

EEF1A2 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV678611 1.0 ug DNA
EUR 818.4

EEF1A2 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV678612 1.0 ug DNA
EUR 818.4

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

20-abx126892
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

20-abx112350
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

abx026885-400ul 400 ul
EUR 627.6

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

abx026885-80l 80 µl
EUR 343.2

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

20-abx321863
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

20-abx321864
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

20-abx225152
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

abx431222-200ul 200 ul
EUR 460.8

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

abx232642-100ug 100 ug
EUR 577.2

Human Elongation Factor 1 Alpha 2 (EEF1A2) ELISA Kit

abx387052-96tests 96 tests
EUR 1093.2

Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1A2) Antibody

20-abx215074
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Bovine Elongation factor 1- alpha 2, EEF1A2 ELISA KIT

ELI-26629b 96 Tests
EUR 1113.6

Mouse Elongation factor 1- alpha 2, Eef1a2 ELISA KIT

ELI-32725m 96 Tests
EUR 1038

Human Elongation factor 1- alpha 2, EEF1A2 ELISA KIT

ELI-09299h 96 Tests
EUR 988.8

Rat Elongation factor 1- alpha 2, Eef1a2 ELISA KIT

ELI-09300r 96 Tests
EUR 1063.2

Rabbit Elongation factor 1- alpha 2, EEF1A2 ELISA KIT

ELI-09609Ra 96 Tests
EUR 1113.6

Recombinant Eukaryotic Translation Elongation Factor 1 Alpha 2 (EEF1a2)

4-RPF021Hu01
  • EUR 496.32
  • EUR 256.80
  • EUR 1531.20
  • EUR 590.40
  • EUR 1060.80
  • EUR 408.00
  • EUR 3648.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Eukaryotic Translation Elongation Factor 1 Alpha 2 expressed in: E.coli

Eef1a2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K6923405 3 x 1.0 ug
EUR 451.2

EEF1A2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0655105 3 x 1.0 ug
EUR 451.2

Eef1a2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K3721705 3 x 1.0 ug
EUR 451.2

Polyclonal Phospho-Ser358 Eukaryotic Elongation Factor 1 alpha 2 (eEF1A2) Antibody

APR03408G 0.1ml
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Phospho-Ser358 Eukaryotic Elongation Factor 1 alpha 2 (eEF1A2) . This antibody is tested and proven to work in the following applications:

Eef1a2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K6923406 1.0 ug DNA
EUR 200.4

Eef1a2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K6923407 1.0 ug DNA
EUR 200.4

Eef1a2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K6923408 1.0 ug DNA
EUR 200.4

EEF1A2 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV678608 1.0 ug DNA
EUR 818.4

EEF1A2 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV678609 1.0 ug DNA
EUR 888

EEF1A2 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV678610 1.0 ug DNA
EUR 888

EEF1A2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0655106 1.0 ug DNA
EUR 200.4

EEF1A2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0655107 1.0 ug DNA
EUR 200.4

EEF1A2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0655108 1.0 ug DNA
EUR 200.4

Eef1a2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K3721706 1.0 ug DNA
EUR 200.4

Eef1a2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K3721707 1.0 ug DNA
EUR 200.4

Eef1a2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K3721708 1.0 ug DNA
EUR 200.4

A number of different research investigating the advantages of ivermectin for malaria functions are ongoing/deliberate.Whereas ivermectin MDA provides promising views within the combat in opposition to malaria, we spotlight the added advantages and anticipated challenges of conducting future research in onchocerciasis-endemic areas, that are confronted with a considerable illness burden together with onchocerciasis-associated epilepsy.

Rising the frequency of ivermectin MDA in such locations could scale back the burden of each malaria and onchocerciasis, and permit for extra entomological investigations on each the Anopheles mosquitoes and the blackflies.

Upfront, acceptability and feasibility research are wanted to evaluate the endorsement by the native populations, in addition to the programmatic feasibility of implementing ivermectin MDA a number of occasions a yr.Onchocerciasis-endemic websites would doubly profit from ivermectin MDA interventions, as these will alleviate onchocerciasis-associated morbidity and mortality, whereas doubtlessly curbing malaria transmission. Involving onchocerciasis applications and different related stakeholders within the malaria/ivermectin analysis agenda would foster the implementation of pluri-annual MDA in goal communities.